FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.
Species Accession # Identity macaca mulatta XM_001102467 78.1% Pan troglodytes XM_518045 89.7% bos taurus NP_001033166 85.6% Pongo abelii XM_002816109 87.8% Mus musculus NM_026342.3 79% Callithrix jacchus XP_002744467 94.7%
Protein The FAM114A2 protein is 505 amino acids longHomo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#! It is predicted to stay in the nucleus after translation PSORT WWW Server There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 STRING: http://string-db.org/newstring_cgi/show_network_section.pl . This protein is thought to include a P loop that suggests a role in ATP- and/or GTP-binding
Gene The FAM114A2 gene is located on chromosome 5 (5q31-33).FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody This gene has 14 exons spanning through its sequence. The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs. It is expressed at high levels in most tissues of the human body. It is also highly expressed in tissues in the human brain Allen Brain Atlas: http://human.brain-map.org/search?type=mi
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