Witherspoon may refer to:
Witherspoon (surname), including a list of people with the name John Witherspoon College, in Rapid City, South Dakota, US Witherspoon Street School for Colored Children, a former school in Princeton, New Jersey, US John Witherspoon Middle School, Princeton, New Jersey, US
See also Weatherspoon, a surname Wetherspoon (surname) Wetherspoons, a British pub company Wotherspoon, a surname Witherspoon Building, in Philadelphia, Pennsylvania, US Witherspoon Cottage, at Saranac Lake, New York, US Witherspoon-Hunter House, in York, South Carolina, US Witherspoon Institute, a think tank in Princeton, New Jersey, US Witherspoon Lodge of Free and Accepted Masons, No. 111, historic building in Mount Dora, Florida, US Witherspoon v. Illinois, a US Supreme Court case regarding selection of jurors in capital cases Witherspoon questions, questions asked of prospective jurors in capital cases in the United States Miss Witherspoon, a 2006 play by Christopher Durang