Ann or Anne Hughes may refer to:
Anne Hughes (politician) (born 1965), American politician from Connecticut Ann Hughes (judoka) (born 1960), British judoka Anne Hughes (art patron) (1944–2021), American gallery owner, restaurateur and patron of the arts Ann Hughes (politician) (born 1943), American politician from Illinois Ann Harriet Hughes (1852–1910), Welsh language novelist Anne Hughes (diarist), author of The Diary of a Farmer's Wife 1796–1797 (also known as Anne Hughes' Diary) Anne Rice Hughes (fl. 1784-1795), British author Anne Penny (1729–1784), née Hughes, British poet and translator