Michael O'Donnell may refer to:
Michael O'Donnell (physician) (1928–2019), British doctor, journalist, author, and broadcaster Michael O'Donnell (Kansas politician) (born 1985), American researcher, and lecturer Michael E. O'Donnell, American biochemist Michael O'Donnell (rugby league), New Zealand former professional rugby league footballer Michael A. O'Donnell, American writer and researcher Michael O'Donnell (Missouri politician), politician in Missouri