Hydrophobia may refer to:
Science Aquaphobia, an irrational fear of water Hydrophobe, the chemical property of a molecule that is seemingly repelled from a mass of water Rabies, historically referred to as hydrophobia, a viral disease that causes encephalitis in humans and other mammals
Art, entertainment, and media Hydrophobia (video game), a 2010 game developed and published by Dark Energy Digital Hydrophobia, a Hungarian disk magazine "Hydrophobia", the 13th track on the Risk of Rain 2 soundtrack album