Very-long-chain 3-oxoacyl-CoA reductase (, very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene), IFA38 (gene)) is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ a very-long-chain 3-oxoacyl-CoA + NADPH + H+
This microsomal complex extends palmitoyl-CoA and stearoyl-CoA (and their modified forms) to very-long-chain acyl CoAs.
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