Holbein is a surname of Germanic origin. It appears to mean "hollow leg" (Hol- + Bein); however, it could also have originally meant "hollow bone" or perhaps even have evolved from Holzbein, which could mean "wooden leg" or "wooden bone".
Some notable people with the surname include:
Hans Holbein the Elder (1460–1524), German painter Hans Holbein the Younger (c. 1497–1543), son of Hans Holbein the Elder, court artist to King Henry VIII of England Ambrosius Holbein (1494–1519), German painter, son of Hans Holbein the Elder Sigmund Holbein (died 1540), German painter, brother of Hans Holbein the Elder Montague Holbein (1861–1944), British cyclist, runner-up of the first Bordeaux–Paris cycle race in 1891 Therese Holbein von Holbeinsberg (1785–1859), Austrian landscape painter and etcher Thomas Holbein (born 1983), French footballer Ulrich Holbein (born 1953), German writer
See also Hohlbein