USS O'Brien has been the name of five ships of the United States Navy, in honor of Jeremiah O'Brien (1744–1818):
, a torpedo boat, built in 1900 and served until 1909. , an O'Brien-class destroyer, which served from 1915 until 1922. , a Sims-class destroyer, served from 1940 until she was sunk by an enemy torpedo in 1942. , an Allen M. Sumner-class destroyer, served from 1944 until 1972. , a Spruance-class destroyer, launched in 1976 and served until 2004.
See also , a Liberty ship, which served during World War II.