Guzzoni is a surname of Italian origin. People with that name include:
Alfredo Guzzoni (1877–1965), Italian military officer who served in both World War I and World War II Didier Guzzoni (born 1970), Swiss computer scientist and inventor of Siri Tommaso Guzzoni (1632–1704), Roman Catholic prelate who served as Bishop of Sora
See also Guzoni (disambiguation)