Issue 1 may refer to:
Ballot measures
Arkansas 2012 Arkansas Issue 1, a successful ballot measure to raise sales tax to pay for highway improvements
Ohio 2004 Ohio Issue 1, a successful ballot measure banning same-sex marriage in the state May 2018 Ohio Issue 1, a successful ballot measure regarding congressional redistricting November 2018 Ohio Issue 1, a failed ballot measure regarding the criminalization of drug possession and usage 2022 Ohio Issue 1, a successful ballot measure regarding cash bail procedures August 2023 Ohio Issue 1, a failed ballot measure regarding the process for proposing and approving amendments to the Ohio state constitution November 2023 Ohio Issue 1, a successful ballot measure codifying abortion rights in the state constitution. 2024 Ohio Issue 1, a redistricting commission initiative
Organizations Issue One, an American non-profit organization that seeks to reduce the role of money in politics
See also First issue Proposition 1