Muthoni is a Kenyan given name and surname. Notable people with the surname include:
Given name
Muthoni Gathecha (born 1962), Kenyan actress Muthoni Kirima (1931–2023), Kenyan guerilla fighter Muthoni Likimani (born 1926), Kenyan writer Muthoni Drummer Queen (born Muthoni Ndonga), Kenyan rapper, drummer and entrepreneur
Surname
Alice Wahome (born Alice Muthoni; 1959), Kenyan politician Muthoni wa Gichuru (born Alice Muthoni Gichuru), Kenyan writer Dorcas Muthoni (born 1979), Kenyan computer scientist and businesswoman Esther Passaris (born Esther Muthoni Passaris; 1964), Kenyan politician Lynne Muthoni Wanyeki (born 1972), Kenyan political scientist, activist and journalist Mary Muthoni Nyanjiru (died 1922), Kenyan activist Teresia Muthoni Gateri (born 2002), Kenyan middle-distance runner