Six Mile Run may refer to the following in the U.S. state of New Jersey:
Six Mile Run (New Jersey), a tributary of the Millstone River Six Mile Run, New Jersey, several different but related features in Franklin Township Six Mile Run Reformed Church, a Dutch Reformed church listed on the NRHP in Somerset County Six Mile Run Reservoir Site, part of the Delaware and Raritan Canal State Park Franklin Park, New Jersey, a community once known as Six Mile Run
See also Six Mile Creek (disambiguation)