His or HIS may refer to:
People Wilhelm His Sr. (1831–1904), Swiss anatomist Wilhelm His Jr. (1863–1934), Swiss anatomist
Places His, Agder, a village in Arendal municipality in Agder county, Norway His, Haute-Garonne, a commune in the Haute-Garonne department, France
Schools Hangzhou International School, in China Harare International School, in Zimbabwe Hokkaido International School, in Japan Hsinchu International School, in Taiwan Hollandsch-Inlandsche School, a Dutch school for native Indonesians in the Dutch East Indies
Science and technology Biology and medicine Angle of His, also known as the esophagogastric angle, at the juncture of the stomach and esophagus Bundle of His, a collection of specialized heart cells Health information system Hospital information system Human identical sequence His-Tag, a polyhistidine motif in proteins Histidine, an amino acid abbreviated as His or H His 1 virus, a synonym of Halspiviridae HIS-1, a long non-coding RNA, also known as VIS1
Computing Health information system Hightech Information System, a Hong Kong graphics card company Honeywell Information Systems Hospital information system Hybrid intelligent system Microsoft Host Integration Server
Engineering High impedance surface
Other uses His, the possessive form of the English-language pronoun he H.I.S. (travel agency), a Japanese travel agency
See also Hiss (disambiguation)